Paweł S. Berezowicz, Barbara Adamik, Andrzej Kübler
Elimination of interleukin-6 and interleukin-8 during continuous veno-venous haemofiltration in intensive care patients
Chair of Anaesthesiology and Intensive Therapy,
Head: prof. A. Kübler. Medical University, Wrocław, Poland
Summary
We have assessed the serum and ultrafiltrate concentrations of interleukiens 6 and 8 in eighteen multiorgan failure patients, aged 18-72 yr, treated with continuous veno-venous haemofiltration and evaluated clinically with APACHE II, SAPS and SOFA scores. Assays were performed (ELISA, Quantikinine, R&D Systems, UL) at the forth hour after beginning of haemofiltration and subsequently every 24 hr. Mean serum and ultrafiltrate concentrations of IL-6 were 289.0 pg/ml and 20.5 pg/ml, respectively. Serum concentration of IL-8 was 708.2 pg/ml and it was lower than in the ultrafiltrare (751.9 pg/ml, 17 patients) The ultrafiltrare/serum concentration ratio varied from 1.094 to 10.87. There was no correlation between clinical scores and interleukin concentration with SOFA and IL-8 being only exception (R=0.39; p<0.05). The IL-8 serum concentration was inversely related to the leucocyte's count (R=-0.3321; p,0.005). In our study we could not eliminate significantly interleukines with the veno-venous haemofiltration.
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