Diabetes is one of the “epidemies” of the XXI^st century. The number of subjects with diabetes is close to half a billion and it is predicted that in the next twenty years it will exceed 600 millions. Diabetes is connected with numerous systemic and organ-related complications, and in spite of the fact that their incidence and prevalence is dependent on many factors, like genetic predisposition, duration of the disease and its control as well as on presence of coexisting diseases and their control, it can be stated that one of those complication will be at some time diagnosed in every patient with diabetes. Therefore a patient may present her- or himself by doctors of different specialties: internist, surgeon, cardiologist, nephrologist, ophthalmologist, neurologist, endocrinologist and others. From the other side, each doctor must in the professional life be confronted with a patient with diabetes, and the more the prevalence of the disease will increase, the greater the chance to meet and treat those patients.